Author Archives: Pigment Disorders Staff

Patients with vitiligo, alopecia areata at increased risk for atopic dermatitis

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Girish C. Mohan, MD, and Jonathan I. Silverberg, MD, PhD, MPH, conducted a literature search of Medline, Embase, Cochrane Library, Google Scholar and 12 additional journals from 1946 to April 5, 2014, to compare the prevalence of atopic dermatitis (AD) among patients with either vitiligo or alopecia areata (AA) and those without either disorder

There were 16 studies of vitiligo and 17 studies of AA included in the final review. Through a pooled analysis that included control patients without vitiligo and control patients without AA, patients with vitiligo or AA were found to have a significantly higher odds of AD than control patients, according to the researchers.

There were higher odds of AD in patients younger than 12 years with early-onset vitiligo compared with patients with late-onset vitiligo, according to pooled analysis of three studies. Patients with alopecia totalis or alopecia universalis had higher odds of AD when compared with patients with patchy alopecia, according to pooled analysis of four studies.

 

DNA variation that makes Gujaratis susceptible to vitiligo identified

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Researchers of M S University’s Department of Biochemistry have identified the prevalence of a DNA sequence variation that makes Gujaratis susceptible to vitiligo, a skin disorder in which white patches of skin appear on different parts of the body.

Gujarat and Rajasthan are known to have highest prevalence of vitiligo. It affects over eight percent of the population in Gujarat making it one of the highest in the country. Major reasons for these skin disorder are oxidative stress (imbalance between oxidants and in-oxidants in the body), neural and genetic factors.

“As part of our studies, we screened genetic samples of over 1,500 vitiligo patients from across Gujarat and found that it is because of SNP that Gujaratis are more vulnerable to this disease. Out of the total screened samples, 908 samples were of women,” said professor Rasheedunnisa Begum, whose study is supported by the Indian Council of Medical Research and Gujarat State Biotechnology Mission, Gandhinagar.

Presently, vitiligo is diagnosed through physical examination, medical history and laboratory tests. Vitiligo is incurable but presently light treatment or excimer laser treatments are used to control the spread of the disease on a patient’s body.

After identifying the DNA sequence variation, MSU researchers are hoping that their study will lead to development of personalized medicines for patients suffering from the skin disorder.

“Findings of our research will lead to development of personalised medicine which can control the spread of vitiligo which is incurable. Personalised medicines can be developed based on the stage of disease in individual patients, duration of the disease, the number of patches on an individual’s body and a few biochemical parameters,” said Begum, who has published over 30 national and international papers on vitiligo.

Focusing on how our skin’s color changes

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The aging face has three basic changes: volume loss, collagen loss and color changes. A lot has been made of the use of fillers such as Juvederm, or fat to replace age-related volume loss.

We have previously written about using topical creams, chemical peels and lasers for the restoration of collagen loss, but this month I want to focus on the color changes that we see in the face and what we can do about them. Like collagen, the three basic modalities for treatment are topical creams, chemical peels and laser.

What makes the three color changes in the face particularly annoying is that most of these changes are “spotty” in nature. What we like to see is smooth, even skin. White, red and brown spots mess this up. Before we consider the benign color changes, a quick word about cancer.

Melanoma is scary — any spots that are changing or look significantly different than other spots need to be evaluated for malignancy.

Now let’s consider white spots. There’s a common reason for white spots include, vitaligo, hypomalanoisis and scars. The only treatable cause is a fungal infection called tinea versicolor.

Unfortunately, for most of those unwanted white spots there is no good treatment. Sunscreen and make-up are the mainstays of treatment. Sunscreen won’t actually help the white; it just reduces the contrast between the patch and the normal skin.

Red in the skin consists of two basic problems-distinct vessels and rosacea.

There are four stages of rosacea, which can range from “rosy” cheeks to severe acne forms of rosacea.

Topical creams can help for mild pinkness to the cheeks, products containing caffeine will temporarily reduce the redness and for more severe forms of rosacea, topical and oral antibiotics are sometime helpful.

The Best Beauty Trends, Products, and Tricks of 2014

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2014 was a big year for beauty—the masses were introduced to oil pulling, fell hard for all things Korean, chugged green juice, and embraced washing their hair a few—and in some cases two—times per week.

Tay Cosmetics: Rose-Marie Swift is a famous New York makeup artist that has created this attractive line of color cosmetics. She’s such an inspiration to the green beauty industry. I’m so in love with her lip and cheek pigment in Illusive. Its creamy but not greasy texture feels photo-shoot professional. It’s one of my favorite go-to products that I can use both day and night.

Glam: I finally find the elusive IOPE Water Fit Lipstick that Jun Ji Hyun wore in the hit K-drama, Love from Another Star. Everyone was so obsessed with emulating her look, it was completely out of stock for awhile. Luckily I was able to snag a few on my trip to Seoul.

Lucky Magazine: I’m obsessed with outlandish colors on my lips. Obsessive Compulsive Cosmetics is one of my favorite brands, they’re vegan and make intense, intense pigments like this chalky periwinkle. I don’t think it looks good on me, per se, but I love it all the same. When I mused to my mom that maybe I’ll wear it on my wedding day next summer, she scowled.

The Cut: My daily makeup routine: Amore Pacific Cushion Compact, Kevyn Aucoin Sensual Skin Enhance, Kevyn Aucoin’s Sensual Glow, Surratt Beauty eyelash curler, and a Dolce and Gabbana eyebrow pencil. Cushion compacts are the latest Korean skin coverage technology and Surratt Beauty makes the world’s best eyelash curler (yes, even better than Shu Uemura).